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Human IL-6 ELISA Kit
RN-CY-EL-005
Interleukin-6 (IL-6) is a 26 kDa glycoprotein comprising 184 amino acids, known for its critical role in inflammation, immune responses, hematopoiesis, and oncogenesis. In healthy adults, circulating IL-6 levels are typically below 5 pg/mL but increase significantly during inflammation. IL-6 is expressed in various cell types, such as adipocytes, fibroblasts, osteoblasts, neurons, and immune cells. Elevated IL-6 levels are linked to numerous conditions, including cardiovascular disease, insulin resistance, type 2 diabetes, asthma, rheumatoid arthritis, and advanced cancers.
ELISA, ELISA kit
Product Overview
Interleukin-6 (IL-6) is a 26 kDa glycoprotein comprising 184 amino acids, known for its critical role in inflammation, immune responses, hematopoiesis, and oncogenesis. In healthy adults, circulating IL-6 levels are typically below 5 pg/mL but increase significantly during inflammation. IL-6 is expressed in various cell types, such as adipocytes, fibroblasts, osteoblasts, neurons, and immune cells. Elevated IL-6 levels are linked to numerous conditions, including cardiovascular disease, insulin resistance, type 2 diabetes, asthma, rheumatoid arthritis, and advanced cancers.
IL-6 functions as a signaling molecule, regulating cell growth, differentiation, and immune responses. It acts through a heterodimeric receptor complex of IL-6R and glycoprotein 130 (gp130), which mediates its effects on immune responses, hematopoiesis, bone metabolism, and cancer progression. IL-6 production is not constitutive but is triggered by factors such as cytokines, lipopolysaccharides, or viral infections. Its diverse effects depend on the target tissues, influencing growth, inhibition, or differentiation.
Due to its involvement in various physiological and pathological processes, IL-6 is a critical biomarker for diagnostic research. Abnormal IL-6 production is often associated with disease progression, making serum level measurement a valuable diagnostic tool.
ELISA Kit Benefits
- Ease of Use: Ready-to-use format; standards and samples can be added directly to the wells, eliminating the need for extensive blocking or rehydration steps.
- Enhanced Performance: High sensitivity, specificity, and reproducibility ensure reliable results.
- Validated for Multiple Sample Types: Fully tested and validated across various sample types.
- Flexible Plate Design: 96-well plate breakable into 12 x 8 well strips for efficient use.
This ELISA kit is an indispensable tool for researchers in India investigating the role of IL-6 in immune responses, inflammation, and disease progression.
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Product Specification
| Protein name | IL-6 |
| Alternate names |
Interleukin-6, B-cell differentiation factor 2, B-cell stimulatory factor 2, CDF, CTL differentiation factor, Hybridoma growth factor, IFN-beta-2 |
| Species reactivity | Human |
| Assay format | Solid-phase Sandwich ELISA (quantitative) |
| Sample type | Serum, Plasma, Cell culture supernatant |
| Sample volume | 100 μL |
| Assay length | 4.5 hrs |
| Analytical sensitivity | <1 pg/mL |
| Assay range |
7.8 – 500 pg/mL |
| Intra-assay CV | <4% |
| Inter-assay CV | <6% |
| Recovery (%) |
Serum: 103.8 |
| Detection & Instrument | Colorimetric, Microplate Reader |
| UniProt ID | (Human) P05231 |
Product Sheet – Human IL-6 ELISA Kit
Handbook – Human IL-6 ELISA Kit
Safety Data Sheet (SDS) – Human IL-6 ELISA Kit
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