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Human IL-17 ELISA Kit
RN-CY-EL-006
The interleukin (IL)-17 family includes six members: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, and IL-17F, with IL-17A being the most extensively studied subtype. IL-17A is a 15-20 kDa glycosylated polypeptide that acts as a proinflammatory cytokine. It is primarily produced by T helper 17 (Th17) cells, along with γδ T cells, natural killer T cells, and innate lymphoid cells. IL-17A forms disulfide-linked homodimers (32-38 kDa) and covalent heterodimers with IL-17F (40-45 kDa). While the IL-17A:F heterodimer is the predominant secreted form, the IL-17A:A homodimer exhibits higher bioactivity. IL-17 plays a vital role in immune defense against extracellular pathogens and is implicated in the development of various autoimmune and inflammatory diseases.
ELISA, ELISA kit
Product Overview
The interleukin (IL)-17 family includes six members: IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, and IL-17F, with IL-17A being the most extensively studied subtype. IL-17A is a 15-20 kDa glycosylated polypeptide that acts as a proinflammatory cytokine. It is primarily produced by T helper 17 (Th17) cells, along with γδ T cells, natural killer T cells, and innate lymphoid cells. IL-17A forms disulfide-linked homodimers (32-38 kDa) and covalent heterodimers with IL-17F (40-45 kDa). While the IL-17A:F heterodimer is the predominant secreted form, the IL-17A:A homodimer exhibits higher bioactivity. IL-17 plays a vital role in immune defense against extracellular pathogens and is implicated in the development of various autoimmune and inflammatory diseases.
IL-17A has gained significant attention for its involvement in regulating immune and inflammatory responses. It promotes neutrophil recruitment and stimulates the production of pro-inflammatory cytokines such as IL-6, IL-8, TNF-α, and IL-1β. Elevated levels of IL-17A are linked to numerous chronic inflammatory conditions, including rheumatoid arthritis, asthma, acute coronary syndrome, multiple sclerosis, systemic lupus erythematosus, and allograft rejection.
ELISA Kit Benefits
- Ease of Use: Ready-to-use format, requiring only the addition of standards and samples, with no need for time-intensive blocking or rehydration steps.
- High Performance: Delivers high sensitivity, specificity, and reproducibility for accurate results.
- Validated Across Multiple Sample Types: Fully tested and validated for diverse research needs.
- Flexible Plate Design: 96-well plate is breakable into 12 x 8 well strips for efficient and cost-effective usage.
This ELISA kit is an excellent choice for researchers in India studying immune responses, inflammation, and chronic inflammatory diseases.
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Product Specification
| Protein name | IL-17 |
| Alternate names |
Interleukin-17A, IL-17A, CTLA-8; CTLA8 cytotoxic T-lymphocyte-associated serine esterase 8; IL-17A cytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8 |
| Species reactivity | Human |
| Assay format | Solid-phase Sandwich ELISA (quantitative) |
| Sample type | Serum, Plasma, Cell culture supernatant |
| Sample volume | 100 μL |
| Assay length | 4.5 hrs |
| Analytical sensitivity | <9 pg/mL |
| Assay range |
15.6 – 1000 pg/mL |
| Intra-assay CV | <4% |
| Inter-assay CV | <11% |
| Recovery (%) |
Serum: 98.2 |
| Detection & Instrument | Colorimetric, Microplate Reader |
| UniProt ID | Q16552 |
Product Sheet – Human IL-17 ELISA Kit
Handbook – Human IL-17 ELISA Kit
Safety Data Sheet (SDS) – Human IL-17 ELISA Kit
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